Products Description of Ganciclovir Sodium CAS#107910-75-8
As one type of 2-deoxyguanine nucleotide analogue, ganciclovir sodium can restrain the duplication process of herpes-type viruses. To achieve biological activity, the substance first gets phosphorylated into its monophosphate variant via the CMV-related protein kinase generated by the UL97 gene. Afterwards, intracellular kinases complete subsequent phosphorylation steps to yield diphosphate and triphosphate metabolites.
Cells infected with cytomegalovirus contain roughly 100-fold concentrated active triphosphate compared with healthy cells, which proves the selective activation inside infected tissues. The activated metabolite may stay functional inside contaminated cells for multiple days.
Its triphosphate derivative suppresses viral DNA generation in two approaches, competing against viral DNA polymerase and embedding itself into viral genetic strands to stop chain extension. This pharmaceutical ingredient delivers reliable therapeutic effects against cytomegalovirus and herpes simplex virus related ailments in clinical practice.
Ganciclovir Sodium Chemical Properties
| English Name | Ganciclovir sodium |
| English Synonyms | GANCICLOVIR SODIUM;2-amino-1,9-dihydro-9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6h-purin-6one sodium salt;9-[[1-(Hydroxymethyl)-2-hydroxyethoxy]methyl]-2-amino-9H-purine-6(1H)-one/sodium, (1:1) salt;Ganciclovir monosodium salt;6H-Purin-6-one, 1,9-dihydro-2-amino-9-((2-hydroxy-1-(hydroxymet hyl)ethoxy)methyl)-, monosodium salt;6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxy-1-(hydroxymet hyl)ethoxy)methyl)-, monosodium salt;Rs 21592 sodium;Unii-02L083W284 |
| CAS Number | 107910-75-8 |
| Molecular Formula | C9H14N5NaO4 |
| Molecular Weight | 279.23 |
| EINECS Number | 641-368-8 |
| Storage conditions | Store at 4°C, protect from light |
| Solubility | Dimethyl sulfoxide: 5 mg/mL (17.91 mM) |
| Form | Solid |
| Color | White to off-white |
| Water solubility | Water: 50 mg/mL (179.06 mM) |
| InChl | InChI=1S/C9H13N504.Na.H/c10-9-12-7-6(8(17)13-9)11-3-14(7)4-18-5(1-15)2-16;;/h3,5,15-16H,1-2,4H2,(H 3,10,12,13,17);; |
| InChIKey | HKZYYRUGZQKKFS-UHFFFAOYSA-N |
| Smiles | C(N1C=NC2C(NC(N)=NC1=2)=O)OC(CO)CO.[NaH] |
Product Application of Ganciclovir Sodium CAS#107910-75-8
Ganciclovir sodium works as an active suppressant targeting viruses from the herpes virus group. Apart from its mainstream medical-related usage, this chemical compound also takes part in laboratory analytical exploration. One typical research direction covers the construction of Raman spectral libraries. Such established data resources support fast, non-destructive detection and preliminary screening work for liquid injectable preparations during pharmaceutical inspection procedures.
