Product Description of Homopiperazine CAS#505-66-8
Homopiperazine, also named 1,4-diazepane, has molecular formula C5H12N2 and molecular weight of 100.16. It is white to pale yellow crystalline solid with melting point of 38–40°C, which will turn viscous liquid when temperature rises above its melting point. This seven-membered nitrogen heterocyclic amine is soluble in water and miscible with many polar organic solvents.
The product is hygroscopic and air-sensitive, requiring hermetic storage under cool, dry conditions. It contains two reactive secondary amine groups, showing good basicity and derivatization capacity for organic synthesis.
Homopiperazine Chemical Properties
| Melting point | 38-40 °C (lit.) |
| Boiling point | 169 °C (lit.) |
| density | 0.95 |
| refractive index | 1.4378 (estimate) |
| Fp | 148 °F |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Crystalline Mass |
| pka | 11.02±0.20(Predicted) |
| color | White to light yellow |
| Water Solubility | Soluble in water. |
| Sensitive | Air Sensitive & Hygroscopic |
| BRN | 102711 |
| CAS DataBase Reference | 505-66-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Homopiperazine(505-66-8) |
| EPA Substance Registry System | 1H-1,4-Diazepine, hexahydro- (505-66-8) |
| Hazard Codes | C,Xi |
| Risk Statements | 21-34 |
| Safety Statements | 26-36/37/39-45-27 |
| RIDADR | UN 3259 8/PG 2 |
| WGK Germany | 1 |
| RTECS | HM3850000 |
| F | 37917 |
| Hazard Note | Irritant/Corrosive |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29339900 |
Product Application of Homopiperazine CAS#505-66-8
This compound is widely adopted in pharmaceutical organic synthesis. It acts as a key starting material for preparing diversified bioactive heterocyclic molecules, including multiple isoquinoline, quinolone and benzylamine derivatives. Its downstream derivatives display prominent pharmacological activities, showing broad research and application prospects in the development of cardiovascular drugs and central nervous system regulators for relieving anxiety, depression and cerebral vascular spasms.
Beyond pharmaceutical synthesis, this compound extends to fine chemical industries. Its amino-substituted derivatives can serve as high-efficiency wetting agents, emulsifiers and detergents. Additionally, it acts as excellent oxidative dye intermediates for keratin fiber coloring, especially applied in professional hair dyeing scenarios with bright color and stable color fastness.
