Product Description of Spermine CAS#71-44-3
Spermine falls into the category of polyamine compounds, which contains two amino groups along with two imino groups. Within biological organisms, this substance is biosynthesized from putrescine, also known as butanediamine, and S-adenosylmethionine under the catalytic effect of multiple enzymes.
Together with spermidine, spermine distributes broadly among bacterial strains and the majority of animal cells. As a vital biomolecule, it takes part in boosting cell proliferation processes. It behaves as a polycationic polyamine under acidic environments and is capable of interacting with DNA molecules originating from viruses and bacteria. Such intermolecular contacts contribute to better stability and flexibility of DNA structures. Besides, spermine represents one indispensable ingredient frequently added to cell-culture medium formulations.
Spermine Chemical Properties
| Melting point | 28-30 (lit.) |
| Boiling point | 150 °C/5 mmHg (lit.) |
| density | 0.937 |
| refractive index | 1.4850 (estimate) |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: 1 M at 20 °C, clear, colorless |
| Appearance | White to off-white crystalline powder or low-melting solid (mp ~28–30 °C; may appear as a pale-yellow oily mass above room temperature). |
| pKa | 10.88±0.19(Predicted) |
| Water Solubility | Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether. |
| Sensitive | Air Sensitive & Hygroscopic |
| Merck | 148743 |
| BRN | 1751791 |
| Stability: | Hygroscopic |
| InChIKey | PFNFFQXMRSDOHW-UHFFFAOYSA-N |
| LogP | -0.543 (est) |
| CAS DataBase Reference | 71-44-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Spermine(71-44-3) |
| EPA Substance Registry System | 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3) |
| Hazard Codes | Xi,C |
| Risk Statements | 36/38-34 |
| Safety Statements | 26-36-45-36/37/39-27 |
| RIDADR | UN 3259 8/PG 2 |
| WGK Germany | 3 |
| RTECS | EJ7230000 |
| F | 46091 |
| TSCA | Yes |
| HazardClass | 8 |
| PackingGroup | III |
| HS Code | 29212900 |
Product Application of Spermine CAS#71-44-3
Spermine is an important natural polyamine compound. It is widely applied as biochemical reagent for molecular-biology research, for nucleic-acid stabilization, DNA precipitation and cell-culture related studies.
It serves as a valuable synthetic building block for organic synthesis, pharmaceutical research and custom molecule preparation. As a polycationic compound, it can electrostatically interact with negatively-charged biomolecules. It can also be used for biochemical research on cell proliferation, aging-related mechanism and neuro-biological studies. Small-scale application in cosmetic research is available at low dosage, while it is not a conventional detergent or surfactant raw material.
